MicroRNA Expression

MicroRNAs are a class of small RNAs that are essential regulators of gene expression and act within the RNA-induced silencing complex to bind mRNAs and suppress translation. Alterations in microRNA expression have been shown to disrupt entire cellular pathways, contributing to a variety of human diseases. MicroRNAs remain difficult to measure due to their short length, relatively small number, sequence similarity, and difficulty to isolate from other small RNA fragments. Our research in this area has focused on: (1) assessing and improving methods to measure microRNA expression, (2) the potential of microRNAs as biomarkers of disease, and (3) quantifying microRNA expression profiles across cell types. Our long-term goal is to advance microRNA research by developing statistical methods that are tailored to the specific complexities of microRNA expression data.

Sami Leon
Sami Leon
Statistics PhD Student
Hongying Sun
Hongying Sun
RNA Computational Scientist at Takeda
Yuewei Fei
Yuewei Fei
MS Student in Computational Biology at Carnegie Mellon University
Benyu Zhou
Benyu Zhou
MS Student in Bioinformatics at Boston University
Qidi Yang
Qidi Yang
MS Student in Computational Biology at Carnegie Mellon University
Zachary Brehm
Zachary Brehm
Statistics PhD Student
Qingyan Lilly Xie
Qingyan Lilly Xie
Data Scientist at Paychex